250+

Global Research Collaborations 

Global Research Collaborations

40+

Owned & Licensed Patents

Owned & Licensed Patents

200+

Published Scientific Studies

Published Scientific Studies

The Hallmarks of Brain Aging

In 2018, a perspective paper published in Cell Metabolism posited 10 hallmarks of brain aging, which include the following changes:  

• Mitochondrial dysfunction  
• Accumulated oxidative damage in cells
• Impaired cellular waste disposal  
• Senescence (death) of neural and glial cells
• Compromised stress response

More clinical investigation is needed, but according to the study, “emerging findings are revealing linkages by which age-related NAD+ depletion is positively related to the 10 hallmarks of brain aging.”

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Nobel Prize Winners

Nobel Prize Winners

NAD+ Supports the Aging Brain

Research supports the hypothesis that boosting cellular NAD+ may help neurons maintain healthy function as you age. A recent study showed an increase in brain NAD+ with supplementation of an NAD+ precursor like Niagen, the active supernutrient in Tru Niagen.  
 
Consequently, it stands to reason that NAD+ precursors can help support healthy neurons in the brain. The maintenance of healthy neurons is directly linked to halting/slowing the 10 hallmarks of brain aging.

The Link Between NAD+ and Brain Aging

NAD+ plays an important role in brain health and is vital to the process of energy production in brain cells. This post explores this connection.

Explore

Brain health—and particularly the aging brain— has become a topic of increasing interest as people continue to live longer. Current science shows us that the brain undergoes clear changes as you age. Like all your other vital organs, the cells in your brain need NAD+ to function properly. The NAD-boosting power of Tru Niagen can help boost brain NAD+ and support those cells in all that they do.

Your Brain Depends on NAD+

Brain NAD+ Declines with Age

Your brain is divided into three main structures—the cerebrum, the cerebellum, and the brain stem. These structures include specialized areas such as the cerebral cortex, basal ganglia, thalamus, hypothalamus, pituitary gland, amygdala (aka the limbic system), pineal gland, and hippocampus, which all contribute to central nervous system function.

Even at rest, this three-pound organ consumes around 20% of your body’s energy. The tissues in your brain contribute to vital processes, including motor performance, cognition, speech, and memory. Essentially, everything you experience is processed through your brain, which arguably makes it the most important organ in your body. 

By now, we know that NAD+ is vital in both cellular energy production and repair. Research has shown that NAD+ plays a key role in the way that neurons adapt to a range of physiological stressors and support processes associated with brain health.   
 
Increased NAD+ has been implicated in healthy brain aging. The first human study to investigate NAD+ levels in the brain showed that brain NAD+ does indeed decline as you age. 

"With the clear preclinical benefits of NR observed in the brains of mice, I look forward to future clinical trial findings from testing in human subjects. In the meantime, the known ability of NR to enhance mitochondrial function and cellular energy makes it a top choice for my own personal daily regimen."  

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Support Brain Health with Tru Niagen

At a time when people continue to look to supplements to support their health in many ways, why not take one that helps to support the cells in your most important organ?  

Be smart when it comes to brain health. Embrace the science of aging smarter with Tru Niagen.

Our most popular offering, Tru Niagen 300mg provides 300mg of Niagen to boost NAD+ in one convenient capsule. We recommend taking 1-3 capsules daily, and offer a 30-, 90-, and 180-day supply to meet your needs.*

Tru Niagen 300mg 

Get daily nourishment for your immune system (from vitamin D, C, and zinc) + daily energy support for your 37.2 trillion cells from our patented flagship supernutrient Niagen.*

Tru Niagen Immune

Get the ultimate NAD+ boost along with powerful support for your immune health and overall vitality by taking both products daily.*

Tru Niagen + Immune Bundle

Brain health—and particularly the aging brain— has become a topic of increasing interest as people continue to live longer. Current science shows us that the brain undergoes clear changes as you age. Like all your other vital organs, the cells in your brain need NAD+ to function properly. The NAD-boosting power of Tru Niagen can help boost brain NAD+ and support those cells in all that they do.

Your Brain Depends on NAD+

Brain health—and particularly the aging brain— has become a topic of increasing interest as people continue to live longer. Current science shows us that the brain undergoes clear changes as you age. Like all your other vital organs, the cells in your brain need NAD+ to function properly. The NAD-boosting power of Tru Niagen can help boost brain NAD+ and support those cells in all that they do.

Your Brain Depends on NAD+